Cells can respond to stalled ribosomes by sensing ribosome collisions and employing quality control pathways. […]
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation新着!!
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT- […]
Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay新着!!
Ribosome collisions are recognized by E3 ubiquitin ligase Hel2/ZNF598, leading to RQC (ribosome-associated qua […]
The collision sensor Hel2 specifically recognizes colliding ribosomes and ubiquitinates the ribosomal protein […]
Ribosome-associated quality control (RQC) is a conserved process degrading potentially toxic truncated nascent […]
Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in ribosomal collisions. Coll […]
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control
Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with intracellular proteins […]
Artificial phase-separating (PS) peptides can be used in various applications such as microreactors and drug d […]
Single-molecule characterization of target search dynamics of DNA-binding proteins in DNA-condensed droplets
Target search models of DNA-binding proteins in cells typically consider search mechanisms that include 3D dif […]