令和5年度 (FY2023)
Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover新着!!

Cells can respond to stalled ribosomes by sensing ribosome collisions and employing quality control pathways. […]

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令和5年度 (FY2023)
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation新着!!

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT- […]

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令和5年度 (FY2023)
Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay新着!!

Ribosome collisions are recognized by E3 ubiquitin ligase Hel2/ZNF598, leading to RQC (ribosome-associated qua […]

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令和5年度 (FY2023)
Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex新着!!

The collision sensor Hel2 specifically recognizes colliding ribosomes and ubiquitinates the ribosomal protein […]

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令和5年度 (FY2023)
Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control

Ribosome-associated quality control (RQC) is a conserved process degrading potentially toxic truncated nascent […]

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令和5年度 (FY2023)
Structural basis for clearing of ribosome collisions by the RQT complex

Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in ribosomal collisions. Coll […]

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令和5年度 (FY2023)
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with intracellular proteins […]

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令和5年度 (FY2023)
Rational design of phase separating peptides based on phase separating protein sequence of p53

Artificial phase-separating (PS) peptides can be used in various applications such as microreactors and drug d […]

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令和5年度 (FY2023)
Single-molecule characterization of target search dynamics of DNA-binding proteins in DNA-condensed droplets

Target search models of DNA-binding proteins in cells typically consider search mechanisms that include 3D dif […]

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令和5年度 (FY2023)
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress

ストレスの多い状況下でも不快な経験を記憶する能力は、ストレスフルな環境で生きる動物にとって危険回避などの生存戦略に重要だと考えられます。この論文では、マウスの不快記憶形成をストレス状況下でも可能にするためには、NFAR2 […]

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