Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1
翻訳での植物の無機栄養ホウ素の感知とそれに伴うタンパク質合成過程の変化を分子レベルで明らかにしました。これまで知られていなかった80Sリボソーム複合体がmRNA上を滑って移動するプロセスが翻訳制御に重要であることを明らか […]
The Evolution of Temperature and Desiccation-Related Protein Families in Tardigrada Reveals a Complex Acquisition of Extremotolerance
クマムシ乾眠関連遺伝子の進化の過程を系統解析したところ、クマムシは２回独立に陸上進出した可能性が示唆された。 Tardigrada is an ecdysozoan lineage famed for its resil […]
Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis
It has been more than 10 years since the hopes for disease modeling and drug discovery using induced pluripote […]
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula
Background: Amyotrophic lateral sclerosis/Parkinsonism-dementia complex in Kii peninsula, Japan (Kii ALS/ […]
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia
Background: Microglia are innate immune cells that are the only residential macrophages in the central ne […]
Is euchromatin really open in the cell?
Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In higher eukaryotic cells, strin […]
POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies
Heterozygous pathogenic variants in POLR1A, which encodes the largest subunit of RNA Polymerase I, were […]
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellu […]
SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice
Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of […]
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related path […]