令和5年度 (FY2023)
The Evolution of Temperature and Desiccation-Related Protein Families in Tardigrada Reveals a Complex Acquisition of Extremotolerance

クマムシ乾眠関連遺伝子の進化の過程を系統解析したところ、クマムシは2回独立に陸上進出した可能性が示唆された。 Tardigrada is an ecdysozoan lineage famed for its resil […]

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令和5年度 (FY2023)
Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis

It has been more than 10 years since the hopes for disease modeling and drug discovery using induced pluripote […]

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令和5年度 (FY2023)
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula

Background: Amyotrophic lateral sclerosis/Parkinsonism-dementia complex in Kii peninsula, Japan (Kii ALS/ […]

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令和5年度 (FY2023)
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia

Background: Microglia are innate immune cells that are the only residential macrophages in the central ne […]

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令和5年度 (FY2023)
Is euchromatin really open in the cell?

Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In higher eukaryotic cells, strin […]

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令和5年度 (FY2023)
POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies

  Heterozygous pathogenic variants in POLR1A, which encodes the largest subunit of RNA Polymerase I, were […]

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令和5年度 (FY2023)
Condensed but liquid-like domain organization of active chromatin regions in living human cells

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellu […]

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令和5年度 (FY2023)
SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice

  Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of […]

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令和5年度 (FY2023)
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related path […]

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令和5年度 (FY2023)
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages

In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactiv […]

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