Is euchromatin really open in the cell?
Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In higher eukaryotic cells, strin […]
POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies
Heterozygous pathogenic variants in POLR1A, which encodes the largest subunit of RNA Polymerase I, were […]
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellu […]
SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice
Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of […]
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related path […]
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages
In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactiv […]
Dominant-negative variants in CBX1 cause a neurodevelopmental disorder
Purpose: This study aimed to establish variants in CBX1, encoding heterochromatin protein 1β (HP1β), as a […]
Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast
The nuclear envelope (NE) is a double-membrane structure consisting of inner and outer membranes that spatiall […]
Replication dynamics identifies the folding principles of the inactive X chromosome
Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome (Xi). How it is establi […]
Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover
Cells can respond to stalled ribosomes by sensing ribosome collisions and employing quality control pathways. […]