令和5年度 (FY2023)
Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control

Ribosome-associated quality control (RQC) is a conserved process degrading potentially toxic truncated nascent […]

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令和5年度 (FY2023)
Structural basis for clearing of ribosome collisions by the RQT complex

Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in ribosomal collisions. Coll […]

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令和5年度 (FY2023)
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with intracellular proteins […]

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令和5年度 (FY2023)
Rational design of phase separating peptides based on phase separating protein sequence of p53

Artificial phase-separating (PS) peptides can be used in various applications such as microreactors and drug d […]

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研究成果
Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling

  オリゴデンドロサイト特異的に発現するRNA結合蛋白質のスクリーニングを行い、RNA結合蛋白質Sbp2Lを同定しました。さらにSbp2Lがオリゴデンドロサイトの成熟に寄与するTcf7l2を介した分子経路を明ら […]

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令和5年度 (FY2023)
Single-molecule characterization of target search dynamics of DNA-binding proteins in DNA-condensed droplets

Target search models of DNA-binding proteins in cells typically consider search mechanisms that include 3D dif […]

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