Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis新着!!
It has been more than 10 years since the hopes for disease modeling and drug discovery using induced pluripote […]
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula新着!!
Background: Amyotrophic lateral sclerosis/Parkinsonism-dementia complex in Kii peninsula, Japan (Kii ALS/ […]
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia新着!!
Background: Microglia are innate immune cells that are the only residential macrophages in the central ne […]
Is euchromatin really open in the cell?
Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In higher eukaryotic cells, strin […]
POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies
Heterozygous pathogenic variants in POLR1A, which encodes the largest subunit of RNA Polymerase I, were […]
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellu […]
SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice
Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of […]
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related path […]
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages
In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactiv […]
Dominant-negative variants in CBX1 cause a neurodevelopmental disorder
Purpose: This study aimed to establish variants in CBX1, encoding heterochromatin protein 1β (HP1β), as a […]