Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages
In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactiv […]
Dominant-negative variants in CBX1 cause a neurodevelopmental disorder
Purpose: This study aimed to establish variants in CBX1, encoding heterochromatin protein 1β (HP1β), as a […]
Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast
The nuclear envelope (NE) is a double-membrane structure consisting of inner and outer membranes that spatiall […]
Replication dynamics identifies the folding principles of the inactive X chromosome
Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome (Xi). How it is establi […]
Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover
Cells can respond to stalled ribosomes by sensing ribosome collisions and employing quality control pathways. […]
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT- […]
Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay
Ribosome collisions are recognized by E3 ubiquitin ligase Hel2/ZNF598, leading to RQC (ribosome-associated qua […]
Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex
The collision sensor Hel2 specifically recognizes colliding ribosomes and ubiquitinates the ribosomal protein […]
Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control
Ribosome-associated quality control (RQC) is a conserved process degrading potentially toxic truncated nascent […]
Structural basis for clearing of ribosome collisions by the RQT complex
Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in ribosomal collisions. Coll […]